In Waifu Slut School, while running to the lady of your dreams after passing your final high school exams, you are struck by an unspeakable vehicle and sent to hell in the blink of an eye. There's a seductive woman-devil there who wants you to work for her and entice women so she can drag them to hell with you. So the She-devil has you go to a strange city full of females who don't want to be there. How did they get here, and the most intriguing question is how do they leave? Is it better to go along with the devil or to assist the females in danger? It's up to you to become the head of the "Waifu Slut School" and determine what happens to yourself and the girls.