In Venomous, MC is a recent high school graduate living with his stepmother, Rebecca. His childhood friend and neighbor, Rachel, has been a constant companion since their school years, and they're getting ready to attend the same university. MC works part-time at a clothing store owned by Rachel's mother, Lucia, to earn extra money. One day, when MC wasn't working, he and Rachel went for a run in the park. After jogging, they rested and talked. But their peaceful time was disturbed when a snake bit MC in a sensitive area. They hurried to the hospital for MC to receive treatment, and afterward, they went back home. However, the following morning held a big surprise for MC.